Professor Arun Seth
Position:
- Director, Molecular Diagnostics Laboratory, Sunnybrook Health Sciences Centre
- Professor , Laboratory Medicine and Pathobiology, University of Toronto
- Academic Director, The Centre for Genomic Studies, Sunnybrook Health Sciences Centre
- Head, Sunnybrook Research Institute Tumour Bank
Websites:
Biography:
Research biography: ETS gene translocations as biomarkers of prostate cancer: In some prostate cancers, we have identified that part of the TMPRSS2 gene that is normally activated by the male sex hormone androgen is translocated upstream of a cancer related ERG gene. Thus the resulting TMPRSS2:ERG fusion gene becomes abnormally active in response to androgen, but only in prostate cancer not in benign tissue. It is therefore a potential marker of malignancy. Our research is designed to test whether screening for this gene in patient blood and tumour samples could predict progression and metastasis of prostate cancer which will be of great utility in aiding clinical management for cancer patients.
Current areas of collaboration: prostate biomarkers; TMAs; microarrays.
ETS gene, biomarkers, cancer initiation, cancer progression, circulating tumor markers, endogenous factors, exogenous factors, genes/genetic polymorphisms, hormone regulation, marker discovery, marker evaluation, oncogenes and tumour suppressor genes, technology development.
tumour microarrays.
