Dr Derek Richard
Position:
- Head, Genomic Stability Laboratory, QUT, Institute of Health Biomedical Innovation (IHBI)
Websites:
Biography:
Dr Richard obtained his PhD in microbial biochemistry from the University of Dundee (Scotland) in 1999. His research interest then moved from the bacterial domain of life to the archaea where he worked as a Postdoctoral Fellow in the laboratory of Prof. Malcolm White studying archaeal DNA repair systems.
During his time at St Andrews University his team made significant progress in understanding the role of the crenarchaeol SSB family of proteins. This research led to the seminal discovery of the human SSB homologues with this work being published in Nature (2008).
Dr Richard moved to Queensland in 2004 to join the team of Prof Kum Kum Khanna at QIMR before transferring his research team to the Institute of Health and Biomedical Innovation at QUT in Feb 2011.
Since moving to Queensland, he works as a consultant for, and has licensed technologies to, Cancer Therapeutics. His latest research led to the initiation of a clinical trial sponsored by Cancer Research UK. In 2006, Dr Richard was awarded the RBWH Sir Ian McFarlane medal.
Dr Richard has published in prestigious journals including, Nature, Genes and Development, Proceedings of the National Academy of Sciences, Journal of Cell Biology, Pathology and Nucleic Acids Research.
His research team investigates the cellular processes that allow cells to cope with genomic stress and how these processes are modified in disease. This research centres taking on the initial basic discoveries to the translation from bench to bedside.
Best publications:
Derek J. Richard, Valérie Schumacher, Brigitte Royer-Pokora, and Stefan G.E. Roberts Par4 is a coactivator for a splice isoform-specific transcriptional activation domain in WT1 Genes & Dev., Feb 2001; 15: 328. (Impact factor 14.2)
Charles S. Bond, Mamuka Kvaratskhelia, Derek Richard, Malcolm F. White, and William N. Hunter Structure of Hjc, a Holliday junction resolvase, from Sulfolobus solfataricus PNAS, May 2001; 98: 5509 - 5514. (Impact factor 9.432)
CL Middleton, JL Parker, DJ Richard, MF White, and CS Bond Crystallization and preliminary X-ray diffraction studies of Hje, a HolliDay junction resolving enzyme from Sulfolobus solfataricus. Acta Crystallogr D Biol Crystallogr, Jan 2003; 59(Pt 1): 171-3. (Impact factor 1.827)
Derek J. Richard, Stephen D. Bell, and Malcolm F. White Physical and functional interaction of the archaeal single-stranded DNA-binding protein SSB with RNA polymerase Nucleic Acids Res., Feb 2004; 32: 1065 - 1074. (Impact factor 6.968)
Claire L. Middleton, Joanne L. Parker, Derek J. Richard, Malcolm F. White, and Charles S. Bond
Substrate recognition and catalysis by the Holliday junction resolving enzyme Hje Nucleic Acids Res., Oct 2004; 32: 5442 - 5451. (Impact factor 7.5)
CR Jekimovs, X Chen, J Arnold, M Gatei, DJ Richard, AB Spurdle, KK Khanna, G Chenevix-Trench, and kConFab Investigators Low frequency of CHEK2 1100delC allele in Australian multiple-case breast cancer families: functional analysis in heterozygous individuals. Br J Cancer, Feb 2005; 92(4): 784-90. (Impact factor 4.637)
Antonio Ariza, Derek J. Richard, Malcolm F. White, and Charles S. Bond Conformational flexibility revealed by the crystal structure of a crenarchaeal RadA Nucleic Acids Res., Mar 2005; 33: 1465 - 1473. (Impact factor 7.5)
Julia K. Pagan, Jeremy Arnold, Kim J. Hanchard, Raman Kumar, Tiziana Bruno, Mathew J. K. Jones, Derek J. Richard, Alistair Forrest, Amanda Spurdle, Eric Verdin, Merlin Crossley, Maurizio Fanciulli, Georgia Chenevix-Trench, David B. Young, and Kum Kum Khanna A Novel Corepressor, BCoR-L1, Represses Transcription through an Interaction with CtBP J. Biol. Chem., May 2007; 282: 15248 - 15257. (Impact factor 5.328)
DJ Richard, E Bolderson, L Cubeddu, RI Wadsworth, K Savage, GG Sharma, ML Nicolette, S Tsvetanov, MJ McIlwraith, RK Pandita, S Takeda, RT Hay, J Gautier, SC West, TT Paull, TK Pandita, MF White, and KK Khanna Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature, May 2008; 453(7195): 677-81. (Impact factor 34.5)
Emma Bolderson, Derek J. Richard, Winfried Edelmann, and Kum Kum Khanna. Involvement of Exo1b in DNA damage-induced apoptosis Nucleic Acids Res., Apr 2009; 10.1093 (Impact factor 7.5)
Derek J Richard, Emma Bolderson, and Kum Kum Khanna. Multiple human single-stranded DNA binding proteins function in genome maintenance: structural, biochemical and functional analysis. Crit Rev Biochem Mol Biol, Apr 2009; 1-19. (Impact factor 9.662)
Yongjiang Li, Emma Bolderson, Rakesh Kumar, Parameswary A Muniandy, YutongXue, Derek J Richard, Michael Seidman, Tej K. Pandita, Kum Kum Khanna, andWeidong Wang. hSSB1 and hSSB2 Form Two Similar Multi-Protein Complexes thatParticipate in the DNA Damage Response. Journal of Biological Chemdistry. August 2009; 284. (Impact factor 5.328)
Jeffrey R. Skaar, Derek J. Richard, Anita Saraf, Alfredo Toschi, Emma Bolderson, Laurence Florens, Michael P. Washburn, Kum Kum Khanna, and Michele Pagano. INTS3 controls the hSSB1-mediated DNA damage response. J. Cell Biol. 2009; 187:25-32. (Impact factor 10.056)
Emma Bolderson, Derek J. Richard, Bin-Bing S. Zhou, and Kum Kum Khanna
Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break Repair
Clin. Cancer Res., Oct 2009; 15: 6314 - 6320. (Impact factor 6.7)
Emma Bolderson, Nozomi Tomimatsu, Derek J Richard, Didier Boucher, Rakesh Kumar, Tej K Pandita, Sandeep Burma and Kum Kum Khanna. Exo1 is required for DNA DSB repair and maintenance of genomic stability. Nucleic Acids Research, Feb 2010; 10.1093/nar/gkp1164. (Impact factor 7.5)
AJ Urquhart, M Gatei, DJ Richard, and KK Khanna ATM mediated phosphorylation of CHD4 contributes to genome maintenance. Genome Integr, Jan 2011; 2(1): 1.
G. Schettino, M. Ghita, D.J. Richard, and K.M. Prise Spatiotemporal investigations of DNA damage repair using microbeams Radiat Prot Dosimetry, Feb 2011; 143: 340 - 343.
Derek J. Richard, Kienan Savage, Emma Bolderson, Liza Cubeddu, Sairei So, Mihaela Ghita, David J. Chen, Malcolm F. White, Kerry Richard, Kevin M. Prise, Giuseppe Schettino, and Kum Kum Khanna hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex Nucleic Acids Res., Mar 2011; 39: 1692 - 1702.
Derek J. Richard, Liza Cubeddu, Aaron J. Urquhart, Amanda Bain, Emma Bolderson, Dinoop Menon, Malcolm F. White, and Kum Kum Khanna hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity Nucleic Acids Res., May 2011; 39: 3643 - 3651.
Ian Paul, Kienan I. Savage, Jaine K. Blayney, Elisabeth Lamers, Kathy Gately, Keith Kerr, Michael Sheaff, Kenneth Arthur, Derek J. Richard, Peter W. Hamilton, Jacqueline A. James, Kenneth J. O’Byrne, D. Paul Harkin, Jennifer E. Quinn, Dean A. Fennell PARP inhibition induces BAX/BAK independent Synthetic Lethality of BRCA1-deficient non-small cell lung cancer Journal of Pathology., May 2011; DOI: 10.1002/ path.2925
Michelle N. Wykes, Derek J Richard, Jay G. Kay, Antony Manderson, Xue Q. Liu, Darren L. Brown, Jiraprapa Wipasa, Suhua H. Jiang, Malcolm K. Jones, Chris J. Janse, Andrew P. Waters, Susan K. Pierce, Louis H. Miller, Jennifer L. Stow and Michael F. Good Rodent blood stage Plasmodium survive in dendritic cells that infect naive mice Proceedings of the National Academy of Sciences., June 2011
Sara Busacca, Michael Sheaff, Kenneth Arthur, Steven G. Gray, Kenneth J. O'Byrne, Derek J. Richard, Alex Soltermann, Isabelle Opitz, Harvey Pass, D. Paul Harkin, Jennifer E. Quinn, Dean A. Fennell BRCA1 is an essential mediator of vinorelbine induced apoptosis in mesothelioma† Journal of Pathology. DOI: 10.1002/path.3979
John D. O’Flaherty, Steven Gray, Derek Richard, Dean Fennell, John J. O’Learyd, Fiona H. Blackhalle, Kenneth J. O’Byrne. Circulating tumour cells, their role in metastasis and their clinical utility in lung cancer. Lung Cancer, (2011). eprint
For more publications by Derek Richard visit QUT ePrints, the University's research repository.
genomic.
