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Dr Ganesh Raj


  • Associate Professor, Department of Urology, UT Southwestern Medical Center at Dallas


  • Associate Professor at UT Southwestern Medical Center at Dallas



Dr. Raj MD. PhD., is an Associate Professor of Urology at UT Southwestern Medical Center. He is a funded cancer investigator with an active clinical practice. He is an experienced and highly regarded prostate cancer surgeon, with significant experience in robotic and minimally invasive approaches. He has training in molecular biology, endocrinology, oncology and has significant experience in the preclinical endocrine agents for human hormonal malignancies. His basic science research laboratory efforts are largely focused on translational strategies against the steroid hormonal receptors. At UT Southwestern, Dr. Raj pioneered and developed a primary human tumor explant culture approach to test the efficacy of new drugs using ex vivo culture of human prostate and breast tumors. His laboratory has recently developed several active peptidomimetic compounds against targeting coregulators-nucl ear receptors including AR and ER. Dr. Raj has significant experience in the area of hormonal signaling, peptidomimetics and urologic oncology.

Best publications:

1. Yang L, Ravindranathan P, Ramanan M, Kapur P, Hammes SR, Hsieh JT, Raj GV. Central Role for PELP1 in nonandrogenic activation of the androgen receptor in prostate cancer. Mol Endrocinol. 2012 Apr;26(4):550-61 PMID:22403175.

2. Ravindranathan P, Lee TK, Yang L, Centenera MM, Butler L, Tilley WD, Hsieh JT, Ahn JM, Raj GV. Peptidomimetic targeting of critical androgen receptor-coregulator interactions in prostate cancer. Nat Comm 2013;4:1923 PMID: 23715282.

3. Mohammed H, Russell IA, Stark R, Rueda OM, Hickey TE, Tarulli GA, Serandour AA, Birrell SN, Bruna A, Saadi A, Menon S, Hadfield J, Pugh M, Raj GV, Brown GD, D'Santos C, Robinson JL, Silva G, Launchbury R, Perou CM, Stingl J, Caldas C, Tilley WD, Carroll JS. Progesterone receptor modulates estrogen receptor-α action in breast cancer. Nature, 2015 Jul 16;523(7560):313-7. doi:10.1038/nature14583. Epub 2015 Jul

4.Centenera MM, Raj GV, Knudsen KE, Tilley WD, Butler LM. Ex vivo culture of human prostate tissue and drug development. Nat Rev Urol 2013 Aug; 10(8): 483-7. Epub 2013 Jun 11 PMID: 23752995.

5. Wang S, Kollipara RK, Srivastava N., Li R, Ravindranathan P, Hernandez E, Freeman E, Humphries CG, Kapur P, Lotan Y, Fazli L, Gleave ME, Plymate R, Raj GV, Hsieh JT, Kittler R. Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer. Proc Natl Acad Sci USA. 2014 Mar 18;111(11): 4251-6. Epub 2014 Mar 3. PMID: 24591637.



Work Focus:

  • Work Focus (Biomedical): Androgen Receptor, Breast Cancer, Drug Development, Prostate Cancer

Androgen Receptor, Drug Development, Prostate Cancer, Breast Cancer.

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