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Dr Charles Graham

Dr Charles Graham


  • Professor and Head, Anatomy and Cell Biology, Queen's University
  • Affiliate, Department of Pharmacology and Toxicology
  • Affiliate, Department of Urology



Dr Charles Graham is Professor and Head of the Department of Anatomy and Cell Biology at Queen’s University, with cross-appointments in the Department of Pharmacology and Toxicology and the Department of Urology. After completing his doctoral studies at the University of Western Ontario and a post-doctoral fellowship at Sunnybrook Health Science Centre in Toronto, he joined Queen's University in 1994. Cancer research in Dr Graham’s laboratory focuses on the biology of malignant progression. Studies from his group have uncovered a novel mechanism by which the local tumour microenvironment, and in particular hypoxia, contributes to drug resistance, metastasis, and immune escape in cancer cells. Specifically, his research has shown that malignant adaptations to hypoxia are closely linked to nitric oxide signalling. This finding has led to the development of new modalities for the treatment of prostate cancer, which are currently under investigation in clinical trials.

Current areas of collaboration: role of hypoxia in cancer progression; use of nitric oxide mimetic drugs in the treatment of prostate cancer (together with Dr. D. Robert Siemens, Department of Urology, Queen’s University).

cancer progression, hypoxia, localized therapies, metastases, prostate cancer, systemic therapies, immune escape, nitric oxide, drug resistance, invasion, , .

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