Dr Grant Buchanan
Position:
- Research Fellow, Medicine, University of Adelaide
- Affiliate, Freemasons Foundation Centre for Mens Health
- Research Fellow, NHMRC CDA
- Research Fellow, BHP Billiton Prostate Cancer Foundation of Australia
Credentials:
- PhD (Cancer Research) at Flinders University
Biography:
Dr Buchanan completed his undergraduate studies in Biochemistry at the University of Tasmania in 1992, his honours degree in Molecular Biology from the University of Adelaide in 1993, and a PhD in Cancer Research jointly at the Flinders University of South Australia in 2002.
His postdoctoral research at the University of Adelaide and the University of Southern California was in high-throughput technology and bioinformatics applied to cancer.
Dr Buchanan’s Molecular Ageing Laboratory Group initiated in 2009 at the University of Adelaide is applying these skills to a deeper understanding of steroid receptors in the cancer microenvironment.
Specifically, his group is looking at how the co-ordinated action of steroid hormones in different compartments of the breast and prostate (e.g. stromal and epithelial cells) control maintenance and homeostasis of these tissues, and how this control breaks down in cancer, ageing and under conditions of hormone intervention. Techniques applied include molecular and cellular biology, next-generation sequencing, bioinformatics, chromatin immunoprecipitation (ChIP), ChIP-sequencing, cloning, expression microarray analysis, high-throughput transcriptional assays, siRNA knockdown, immunoblot analysis, drug screening, confocal microscopy, cellular signaling and novel animal models.
Current areas of collaboration: cancer associate fibroblasts; TGFb signalling; ChIP-sequencing of steroid receptors; Androgen receptor immunohistochemistry.
prostate cancer.
