Associate Professor Marcel Dinger
Position:
- Head, Kinghorn Centre for Clinical Genomics, Kinghorn Centre for Clinical Genomics, Garvan Institute for Medical Research, Garvan Institute for Medical Research
Websites:
Biography:
Marcel Dinger is the Head of the Kinghorn Centre for Clinical Genomics (KCCG) at the Garvan Institute of Medical Research and conjoint Associate Professor at UNSW Australia. As Head of KCCG, he brings together his combination of skills in informatics, genome biology and business to manage and direct a world-class genomics facility at the Garvan. KCCG was one of the first sites in the world to implement the HiSeq X Ten genome sequencing platform, which has capacity to sequence 18,000 whole human genomes per year. The aims of the Centre are to establish genomic medicine in routine healthcare and to leverage clinical genomic data for research.
In addition to his role as Head of KCCG, Dr Dinger heads a research lab that aims to unlock the clinical value of noncoding regions of the genome. Dr Dinger has made numerous key contributions to the field of long noncoding RNAs, including seminal studies showing the highly specific spatial and temporal expression of this molecular class.
Dr Dinger has worked in informatics and genomics since 1998 in both commercial and academic capacities. Attracting more than 6,500 citations (H-index 29), he has (co)-authored 60 papers, many of which appear in the most high profile journals in the life sciences. Dr Dinger has been an invited speaker, both nationally and internationally, on numerous occasions and is recipient of several highly competitive awards and fellowships, including an NHMRC Career Development Award and a Queensland Government Smart Futures Fellowship.
Best publications:
Clark MB, Mercer TR, Bussotti G, Leonardi T, Haynes KR, Crawford J, Lê Cao K, Brunck ME, Thomas GP, Taft RJ, Nielsen LK, Enright AJ, Mattick JS and Dinger ME (2015). Quantitative profiling of long noncoding RNAs with targeted RNA sequencing. Nature Methods 12:392-395.
Clark MB, Johnston RL, Inostroza-Ponta M, Fox AH, Fortini E, Moscato P, Dinger ME*, Mattick JS* (2012). Genome-wide analysis of long noncoding RNA stability. Genome Research 22: 885-898.
Mercer TR, Dinger ME, Mattick JS (2009). Long noncoding RNAs: insights into function. Nature Reviews Genetics. 10: 155-159.
Dinger ME, Amaral PP, Mercer TR, Pang KC, Bruce SJ, Gardiner BB, Askarian-Amiri ME, Ru K, Soldà G, Simons C, Sunkin SM, Crowe ML, Grimmond SM, Perkins AC, Mattick JS (2008).Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. Genome Research 18: 1433-1445.
Mercer TR, Dinger ME, Sunkin SM, Mehler MF, Mattick JS (2008). Specific expression of long noncoding RNAs in the adult mouse brain. Proc Natl Acad Sci USA 105: 716-721.
cancer genetics, cancer progression, endogenous factors, exogenous factors, genes/genetic polymorphisms, localized therapies, marker discovery, model systems, non-coding RNA, normal functioning, prognostic markers, prostate cancer, technology development.
