Dr Nicole Moore
Position:
- Research Manager, School of Medicine, University of Adelaide
Credentials:
- PhD at University of Adelaide
Biography:
Nicole completed a PhD at the University of Adelaide in 2004 where she studied mechanisms of androgen receptor action in breast cancer. She undertook post-doctoral training at Baylor College of Medicine in Houston, TX where she characterised the role of the cell cycle proteins cyclin A and Cdk1/2 in regulating progesterone receptor activity in breast cancer cells, focussing on phosphorylation of the coactivator SRC-1 by Cdks. Nicole was awarded a Cancer Council SA Cancer Research Fellowship which prompted her return to Adelaide to study the molecular mechanisms of action of the synthetic progestin medroxyprogesterone acetate in breast cancer cells. She also has a keen interest in the role of androgen receptor function in different breast cancer subtypes. In 2015, she commenced a research management position in the Prostate Cancer Research Group at SAHMRI, coordinating the Adelaide-based Movember Revolutionary Team Award program investigating lipid metabolism in prostate cancer.
Best publications:
1. Moore, N.L.; Edwards, D.P.; Weigel, N.L. Cyclin A2 and its associated kinase activity are required for optimal induction of progesterone receptor target genes in breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology, 2014; 144:471-482
2. Ochnik, A.M.; Moore, N.L.; Jankovic-Karasoulos, T.; Bianco-Miotto, T.; Ryan, N.K.; Thomas, M.R.; Birrell, S.N.; Butler, L.M.; Tilley, W.D.; Hickey, T.E. Antiandrogenic actions of medroxyprogesterone acetate on epithelial cells within normal human breast tissues cultured ex vivo. Menopause, 2014; 21(1):79-88
3. Moore, N.; Buchanan, G.; Harris, J.; Selth, L.; Bianco-Miotto, T.; Hanson, A.; Birrell, S.; Butler, L.; Hickey, T.; Tilley, W. An androgen receptor mutation in the MDA-MB-453 cell line model of molecular apocrine breast cancer compromises receptor activity. Endocrine-Related Cancer, 2012; 19(4):599-613
4. Moore, N.L.; Weigel, N.L. Regulation of progesterone receptor activity by cyclin dependent kinases 1 and 2 occurs in part by phosphorylation of the SRC-1 carboxyl-terminus. The International Journal of Biochemistry & Cell Biology, 2011; 43(8):1157-1167
5. Peters, A.; Buchanan, G.; Ricciardelli, C.; Bianco-Miotto, T.; Centenera, M.; Harris, J.; Jindal, S.; Segara, D.; Jia, L.; Moore, N.; Henshall, S.; Birrell, S.; Coetzee, G.; Sutherland, R.; Butler, L.; Tilley, W. Androgen receptor inhibits estrogen receptor-alpha activity and is prognostic in breast cancer. Cancer Research, 2009; 69(15):6131-6140
cell biology, prostate cancer, breast cancer, hormone action, cell signalling.
