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Professor Paul Li

Professor Paul Li


  • Professor, Chemistry, Simon Fraser University


  • PhD at University of Toronto



Dr Paul Li obtained his Ph.D in the University of Toronto in 1995. Then he developed the microfluidic lab-on-a-chip at the University of Alberta and City University of Hong Kong.

Dr Li joined Simon Fraser University in 1999, and became full professor in 2010. Dr Li conducted microfluidic single-cell analysis for analyzing the effects of chemical compounds on individual cancer cells. He has also developed the nanobioarray chip to detect single base-pair cancer gene mutation.

Dr Li has published a monograph: Fundamentals of lab on a chip for biological analysis and discovery. He is associate editor of the international journal called “Canadian Journal of Pure and Applied Sciences”. Dr Li is the inventor of 4 granted patents and 5 pending patents, and he is the founder of ZellChip Technologies Inc. specializing in microfluidic-based instrument for cellular and DNA analysis.

Best publications:

  • Xiujun Li, Yuchun Chen, Paul C.H. Li, A simple and fast microfluidic approach of same-single-cell analysis (SASCA) for the study of multidrug resistance modulation in cancer cells, LabChip, 2011, 11, 1378-1384.
  • Lin Wang and Paul C.H. Li, Gold nanoparticle-assisted single base-pair mismatch discrimination on a microfluidic microarray device, Biomicrofluidics, 2010, 4, 032209.
  • Lin Wang and Paul C.H. Li, Optimization of a microfluidic microarray device for the fast discrimination of fungal pathogenic DNA, Analytical Biochemistry, 2010, 400, 282-288.
  • Paul C.H. Li, Elena Lam, Wynand P. Roos, Margaret Z. Zdzienicka, Bernd Kaina, Thomas Efferth, Artesunate derived from traditional Chinese medicine induces DNA damage and repair, Cancer Research, 2008, 68, 4347-4351.
  • Hong Chen, Lin Wang, Paul C.H. Li , Nucleic acid microarrays created in the double-spiral format on a circular microfluidic disc , LabChip, 2008, 8, 826-829.

microfluidics, single cell analysis, multidrug resistance, nanobioarray chip, single base-pair discrimination,.

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