Dr Rae-Anne Hardie

Position:

• Post Doctoral Scientist, Origins of Cancer, Centenary Institute

Credentials:

• Ph.D. Medicine at Garvan Institute, University of New South Wales (currently studying)
• M.Sc. Medical Microbiology at University of Manitoba (currently studying)
• B.Sc. Genetics Hons at University of Manitoba (currently studying)

Biography:

Rae-Anne is Canadian but has been living, studying, and now working in Sydney since 2008. She recently completed her Ph.D. at the Garvan Institute under the International Postgraduate Research Scholarship and Beth Yarrow Memorial Scholarship, with her thesis entitled “Mitochondrial Genetic Variation in the Evolution of Humans and Metabolism of Cancer”.  Rae-Anne was awarded the Lorne Cancer Conference Student Poster Presentation Award, several international travel bursaries, and was selected as a speaker at the Lowy Cancer Symposium. She was a SIEF-AAS Fellow attending the Nobel Laureate Meeting in Lindau, Germany in 2014. Rae-Anne is now researching the role of nutrient transporters and metabolic adaptations to androgen therapy in prostate cancer under the guidance of Jeff Holst at the Centenary Institute in Sydney.

Best publications:

1. Tindall EA, Monare R, Petersen DC, van Zyl S, Hardie RA, Segone A, Venter P, Bornman R, Hayes V. Clinical presentation of prostate cancer in Black South Africans. The Prostate. 2014 7(8):880-891.
2. Petersen DC, Libiger O, Tindall EA, Hardie RA, Hannick LI, Glashoff RH, Mukerji M, Indian Genome Variation Consortium, Fernandez W, Haacke W, Schork N, Hayes VM. Complex Patterns of Genomic Admixture within Southern Africa. PLoS Genetics. 2013 9(3):e1003309.
3. Miller W, Hayes VM, Ratan A, Petersen DC, Wittekindt NE, Miller J, Walenz B, Knight J, Qi J, Zhao F, Wang Q, Bedoya-Reina OC, Katiyar N, Tomsho LP, McClellan Kasson L, Hardie RA, Woodbridge P, Tindall EA, Bertelsen MF, Dixon D, Pyecroft S, Helgen KM, Lesk AM, Pringle TH, Patterson N, Zhang Y, Kreiss A, Woods GM, Jones ME, Schuster SC. Genetic diversity and population structure of the endangered marsupial Sarcophilus harrisii (Tasmanian devil). Proc Natl Acad Sci U.S.A. 2011 Jun 27 108(30):12348-53. 
4. Hardie RA, Knight E, Bruneau B, Semeniuk C, Gill K, Nagelkerke N, Kimani J, Wachihi C, Ngugi E, Luo M, Plummer FA. A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers. AIDS. 2008 22:2035-2044.
5. Hardie RA, Luo M, Bruno B, Knight E, Nagelkerke N, Kimani J, Wachihi W, Ngugi E, Plummer FA. Human leukocyte antigen-DQ alleles and haplotypes and their associations with resistance and susceptibility to HIV-1 infection. AIDS.  2008.  22:807-816.

Research keywords and interests: Prostate cancer, Nutrient transporters, mitochondria, metabolomics, glutamine, genome sequencing, genetics, somatic mutations, respirometry, Tumour metabolism, Metabolism.