Dr Sally-Anne Stephenson
Position:
- Lecturer and Group Leader, Eph Receptor Biology Group, QUT, Institute of Health and Biomedical Innovation
Biography:
Dr Stephenson is a Lecturer in the Faculty of Health, School of Biomedical Science, Queensland University of Technology. She is also Group Leader of the Eph Receptor Biology Group, part of the Cancer Research Program in the Institute of Health and Biomedical Innovation, QUT.
Her main research interest is the EphB4 receptor tyrosine kinase and the contribution that it makes to epithelial cancers including prostate cancer.
The Eph Receptor Biology Group is exploring (1) the consequences of over-expression of EphB4, (2) the sub-cellular localisation of the protein, (3) protease regulation of signaling, (4) activated intracellular signaling pathways and (5) the identification of interacting proteins.
The ultimate goal of this research is to identify new options for targeting this protein to provide options for the development of new anti-cancer therapies.
Best publications:
Rutkowski R, Mertens-Walker I, Lisle JE, Herington AC, Stephenson SA. (2011) Evidence for a dual function of EphB4 as tumor promoter and suppressor regulated by the absence or presence of the ephrin-B2 ligand. Int J Cancer. doi: 10.1002/ijc.27392.
Stephenson SA, Slomka S, Douglas EL, Hewett PJ, Hardingham JE. (2001) Receptor protein tyrosine kinase EphB4 is up-regulated in colon cancer. BMC Mol Biol. 2:15.
Stephenson SA, Verity K, Ashworth LK, Clements JA. (1999) Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3-13.4. J Biol Chem. 274(33):23210-4.
Harvey TJ, Hooper JD, Myers SA, Stephenson SA, Ashworth LK, Clements JA. (2000) Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4. J Biol Chem. 275(48):37397-406.
Rae FK, Stephenson SA, Nicol DL, Clements JA. (2000) Novel association of a diverse range of genes with renal cell carcinoma as identified by differential display. Int J Cancer. 88:726-32.
EphB4 receptor tyrosine kinase, epithelial cancers.
Lab Reagents:
- Antibodies: EphB4 monoclonal antibodies
- Cell Lines: 22Rv1-B4 - 22Rv1 cells over-expressing EphB4, MCF10A-B4 - MCF-10A cells over-expressing EphB4
