Dr Sujeeve Jeganathan, PhD
Position:
- Postdoctoral Fellow, University Health Network, Princess Margaret Cancer Centre
Credentials:
- Postdoctoral Fellow at University of Toronto
Biography:
I completed my Ph.D. in Biochemistry at the University of Ottawa. My dissertation focused on the role of protein elongation factor 1 alpha 2 (eEF1A2) in breast cancer. I identified that the EEF1A2 oncogene promoted oncogenesis by binding to and activating phosphatidylinositol-4 kinase beta. This, in turn, activated PI3K signalling, leading to filopodia / lamellipodia formation in breast cancer cells. This morphological change led to cells with increased migration and invasion capabilities. Following my degree, I was a Visiting Scholar at Massachusetts General Hospital (Harvard Medical School) where I became familiar with lentiviral shRNA-based high throughput screening protocols. Following this, I became a postdoctoral fellow at the University of Toronto where I investigated Chlamydia infections in immune and cancer cells. I also looked into the role of mTOR signalling in this process.
I am currently working at the Princess Margaret Cancer Centre (Toronto, Canada) where I am using kinome-shRNA lentiviral libraries and chemical compound inhibitor screens to identify the means by which prostate cancer cell lines gain resistance to Enzalutamide, an androgen receptor antagonist.
Best publications:
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Sun, HS., Eng, EW., Jeganathan, S., Sin, AT., Patel, PC., Gracey, E., Inman, RD., Terebiznik, MR., and Harrison, RE. Chlamydia trachomatis vacuole maturation in infected macrophages. J Leukoc Biol 2012, 92(4):815-27.
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Jeganathan, S., Morrow, A., Amiri, A., and Lee, JM. Eukaryotic elongation factor 1A2 cooperates with phosphatidylinositol-4 kinase III beta to stimulate production of filopodia through increased phosphatidylinositol-4,5 bisphosphate generation. Mol Cell Biol 2008, 28:4549-4561.
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Jeganathan, S. and Lee, JM. Binding of elongation factor eEF1A2 to phosphatidylinositol-4 kinase beta stimulates lipid kinase activity and phosphatidylinositol-4 phosphate generation. J Biol Chem 2007, 282:372-380.
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Amiri, A., Noei, F., Jeganathan, S., Kulkarni, G, Pinke, DE. and Lee, JM. eEF1A2 activates Akt and stimulates Akt-dependent actin remodeling, invasion and migration. Oncogene 2007, 26:3027-3040.
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Kulkarni, G., Turbin, DA, Amiri, A, Jeganathan, S., Andrade-Navarro, MA, Wu, TD, Huntsman, DG, and Lee, JM. Expression of protein elongation factor eEF1A2 predicts favorable outcome in breast cancer. Breast Cancer Res Treat 2007, 102:31-41.
Prostate Cancer, Breast Cancer, Cell Morphology, Metastasis, Immune Regulation, Cell Biology.
