Dr Thomas Cordonnier
Position:
- Postdoctoral Research fellow, Vancouver Prostate Centre
Credentials:
- PhD at Université François-Rabelais de Tours (France)
Websites:
Biography:
My work in the Vancouver Prostate Centre focuses on the mechanisms of epithelial-to-mesenchymal transition (EMT). More specifically my efforts are concentrated on the role of Hsp27 in EGF-induced EMT in prostate cancer. The epidermal growth factor (EGF) and its associated receptor (EGFR) and also the heat shock protein 27 (Hsp27) are increased in CRPC and facilitates EMT. We suggest that increased Hsp27 enhances EGF-induced EMT and thereby metastasis. The aim of my work is to establish that Hsp27 is a central “node” for several signaling pathways known to modulate EMT. We are conducting a comprehensive analysis of in vitro and in vivo models to demonstrate that Hsp27 mediates EMT through EGF signaling pathways.
Best publications:
Cordonnier T., Layrolle P., Langonné A., Corre P., Renaud A., Sensebé L., Rosset P., Sohier J. “Interest of a biomimetic approach combining ceramic and cell-synthesized 3D environment for bone tissue engineering” Accepted in Journal of Tissue Engineering and Regenerative Medicine, April 2012.
Cordonnier T., Sohier J., Sensebé L., Layrolle P., Rosset P. “Healing of Long-Bone Defects in Metatarsus of Sheep using Bioceramics and Mesenchymal Stem Cells” Accepted in Journal of Current Orthopaedic Practice, March 2012.
Cordonnier T., Sohier J., Rosset Ph., Layrolle P. “Bone Tissue Engineering using Biomimetic Materials and Approaches – State of the Art and Future Trends”. Advanced Engineering Materials, May 2011, 13: B135–B150. doi: 10.1002/adem.201080098
Cordonnier T., Langonné A., Sohier J., Layrolle P., Rosset P., Sensebé L., Deschaseaux F. “Consistent Osteoblastic Differentiation of Human Mesenchymal Stem Cells with Bone Morphogenetic Protein 4 and Low Serum”. Tissue Engineering Part C: Methods. March 2011, 17(3): 249-259. doi:10.1089/ten.tec.2010.0387
Cordonnier T., Layrolle P., Gaillard J., Langonné A., Sensebé L., Rosset P., Sohier J. “3D environment on Human Mesenchymal Stem Cells Differentiation for Bone Tissue Engineering”. J Mater Sci Mater Med. 2010 March ;21(3):981-7. Epub 2009 Oct 25. doi:10.1007/s10856-009-3916-9
Epithelial to mesenchymal transition, Hsp27, Prostate cancer, Metastases, Cancer progression, Stem cells, Tissue engineering.
